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2021 SEASON · WEEK 16

NFL Week 16 2021 ATS results

Favorites went 8-8 against the spread (50.0%) and home teams 8-8 (50.0%). 6 underdogs won outright. The biggest cover: Dallas Cowboys beat the number by 31.5 points in WAS @ DAL. Games finished 9 over and 7 under the total.

Updated Oct 2, 2026

Week 16 results against the spread

Spread shown as the favorite and points; total = combined points vs the posted line.

MatchupDayFinalSpreadCoveredTotal
San Francisco 49ers@Tennessee TitansThuSF 17, TEN 20SF -3.5Tennessee Titans by 6.537 vs 45.5 Under
Cleveland Browns@Green Bay PackersSatCLE 22, GB 24GB -7.5Cleveland Browns by 5.546 vs 46.5 Under
Indianapolis Colts@Arizona CardinalsSatIND 22, ARI 16ARI -3Indianapolis Colts by 938 vs 48 Under
Detroit Lions@Atlanta FalconsSunDET 16, ATL 20ATL -7.5Detroit Lions by 3.536 vs 42.5 Under
Tampa Bay Buccaneers@Carolina PanthersSunTB 32, CAR 6TB -11.5Tampa Bay Buccaneers by 14.538 vs 44.5 Under
Baltimore Ravens@Cincinnati BengalsSunBAL 21, CIN 41CIN -7.5Cincinnati Bengals by 12.562 vs 43 Over
Los Angeles Chargers@Houston TexansSunLAC 29, HOU 41LAC -13.5Houston Texans by 25.570 vs 46 Over
Los Angeles Rams@Minnesota VikingsSunLA 30, MIN 23LA -3.5Los Angeles Rams by 3.553 vs 48.5 Over
Buffalo Bills@New England PatriotsSunBUF 33, NE 21NE -1Buffalo Bills by 1354 vs 43.5 Over
Jacksonville Jaguars@New York JetsSunJAX 21, NYJ 26NYJ -2.5New York Jets by 2.547 vs 42.5 Over
New York Giants@Philadelphia EaglesSunNYG 10, PHI 34PHI -11Philadelphia Eagles by 1344 vs 41 Over
Chicago Bears@Seattle SeahawksSunCHI 25, SEA 24SEA -7Chicago Bears by 849 vs 41 Over
Pittsburgh Steelers@Kansas City ChiefsSunPIT 10, KC 36KC -10.5Kansas City Chiefs by 15.546 vs 44 Over
Denver Broncos@Las Vegas RaidersSunDEN 13, LV 17DEN -1Las Vegas Raiders by 530 vs 42 Under
Washington Commanders@Dallas CowboysSunWAS 14, DAL 56DAL -10.5Dallas Cowboys by 31.570 vs 45.5 Over
Miami Dolphins@New Orleans SaintsMonMIA 20, NO 3MIA -3Miami Dolphins by 1423 vs 37.5 Under

Trifecta's five most confident picks that week, graded: Week 16, 2021 recap.

What ATS means

ATS means against the spread. A team covers when it wins by more than the point spread, or loses by fewer points than the spread. A game that lands exactly on the spread is a push and is left out of cover percentages.

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Regular-season games only, using each game's point spread and final score. Cover % = covers / (covers + non-covers). Past performance doesn't guarantee future results. Trifecta is not affiliated with or endorsed by the NFL or any team. Data notes. Ad: SmackTok is a paid partner. Trifecta earns a commission on sign-ups with code TRIFECTA. 21+, select states.