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2021 SEASON · WEEK 1

NFL Week 1 2021 ATS results

Favorites went 4-12 against the spread (25.0%) and home teams 7-9 (43.8%). 9 underdogs won outright. The biggest cover: New Orleans Saints beat the number by 39 points in GB @ NO. Games finished 7 over and 9 under the total.

Updated Oct 2, 2026

Week 1 results against the spread

Spread shown as the favorite and points; total = combined points vs the posted line.

MatchupDayFinalSpreadCoveredTotal
Dallas Cowboys@Tampa Bay BuccaneersThuDAL 29, TB 31TB -10Dallas Cowboys by 860 vs 52.5 Over
Philadelphia Eagles@Atlanta FalconsSunPHI 32, ATL 6ATL -3.5Philadelphia Eagles by 29.538 vs 49 Under
Pittsburgh Steelers@Buffalo BillsSunPIT 23, BUF 16BUF -6.5Pittsburgh Steelers by 13.539 vs 48 Under
New York Jets@Carolina PanthersSunNYJ 14, CAR 19CAR -3.5Carolina Panthers by 1.533 vs 44.5 Under
Minnesota Vikings@Cincinnati BengalsSunMIN 24, CIN 27MIN -3Cincinnati Bengals by 651 vs 47 Over
San Francisco 49ers@Detroit LionsSunSF 41, DET 33SF -9.5Detroit Lions by 1.574 vs 46 Over
Jacksonville Jaguars@Houston TexansSunJAX 21, HOU 37JAX -3.5Houston Texans by 19.558 vs 45.5 Over
Seattle Seahawks@Indianapolis ColtsSunSEA 28, IND 16SEA -3Seattle Seahawks by 944 vs 49 Under
Arizona Cardinals@Tennessee TitansSunARI 38, TEN 13TEN -2.5Arizona Cardinals by 27.551 vs 54 Under
Los Angeles Chargers@Washington CommandersSunLAC 20, WAS 16WAS -2.5Los Angeles Chargers by 6.536 vs 45.5 Under
Cleveland Browns@Kansas City ChiefsSunCLE 29, KC 33KC -5.5Cleveland Browns by 1.562 vs 54.5 Over
Miami Dolphins@New England PatriotsSunMIA 17, NE 16NE -3.5Miami Dolphins by 4.533 vs 43.5 Under
Green Bay Packers@New Orleans SaintsSunGB 3, NO 38GB -4New Orleans Saints by 3941 vs 49 Under
Denver Broncos@New York GiantsSunDEN 27, NYG 13DEN -3Denver Broncos by 1140 vs 41.5 Under
Chicago Bears@Los Angeles RamsSunCHI 14, LA 34LA -9.5Los Angeles Rams by 10.548 vs 46 Over
Baltimore Ravens@Las Vegas RaidersMonBAL 27, LV 33BAL -3Las Vegas Raiders by 960 vs 50.5 Over

Trifecta's five most confident picks that week, graded: Week 1, 2021 recap.

What ATS means

ATS means against the spread. A team covers when it wins by more than the point spread, or loses by fewer points than the spread. A game that lands exactly on the spread is a push and is left out of cover percentages.

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Regular-season games only, using each game's point spread and final score. Cover % = covers / (covers + non-covers). Past performance doesn't guarantee future results. Trifecta is not affiliated with or endorsed by the NFL or any team. Data notes. Ad: SmackTok is a paid partner. Trifecta earns a commission on sign-ups with code TRIFECTA. 21+, select states.