Detroit Lions at Buffalo Bills, Highmark Stadium. Thu Sep 17, 8:15 PM ET. The line: BUF -5.5; total 54.5. This season the Lions are 0-2-1 against the spread and the Bills 3-0.
Updated Oct 2, 2026
Buffalo Bills covered by 4.5 points. The game finished over the total of 54.5.
The last column is the Lions on the road and the Bills at home.
| Team | 2026 | 2025 | Since 2021 | Away / home since 2021 |
|---|---|---|---|---|
| Detroit Lions | 0-2-1 (0.0%) | 8-9 (47.1%) | 54-31-3 (63.5%) | 28-16 (63.6%) |
| Buffalo Bills | 3-0 (100.0%) | 8-9 (47.1%) | 45-39-3 (53.6%) | 22-19-2 (53.7%) |
| Date | Matchup | Final | Spread | Covered |
|---|---|---|---|---|
| 2026-09-17 | DET @ BUF | DET 31, BUF 41 | BUF -5.5 | Buffalo Bills by 4.5 |
| 2024-12-15 | BUF @ DET | BUF 48, DET 42 | DET -2.5 | Buffalo Bills by 8.5 |
| 2022-11-24 | BUF @ DET | BUF 28, DET 25 | BUF -10 | Detroit Lions by 7 |
ATS means against the spread. A team covers when it wins by more than the point spread, or loses by fewer points than the spread. A game that lands exactly on the spread is a push and is left out of cover percentages.
All Week 2 games · ATS standings · Detroit Lions ATS record · Buffalo Bills ATS record
This page shows history and the posted line only. It is not a prediction.
The model's Thursday Night Football pick, free every week, plus first look at each week's deal.
Regular-season games only, using each game's point spread and final score. Cover % = covers / (covers + non-covers). Past performance doesn't guarantee future results. Trifecta is not affiliated with or endorsed by the NFL or any team. Data notes. Ad: SmackTok is a paid partner. Trifecta earns a commission on sign-ups with code TRIFECTA. 21+, select states.