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WEEK 1 · THU SEP 10, 8:35 PM ET

49ers vs Rams: Week 1, 2026

San Francisco 49ers vs Los Angeles Rams at a neutral site, Melbourne Cricket Ground (Rams are the designated home team). Thu Sep 10, 8:35 PM ET. The line: LA -3.5; total 47.5. This season the 49ers are 2-1 against the spread and the Rams 1-2.

Updated Oct 2, 2026

Final: SF 27, LA 7

San Francisco 49ers covered by 23.5 points. The game finished under the total of 47.5.

Against the spread: both teams

Neutral-site game: the last column is each team's record in neutral-site games. Home and road records on this site leave neutral-site games out.

Team20262025Since 2021Neutral site since 2021
San Francisco 49ers2-1 (66.7%)11-6 (64.7%)47-41 (53.4%)2-0 (100.0%)
Los Angeles Rams1-2 (33.3%)12-5 (70.6%)47-39-2 (54.7%)1-1 (50.0%)

49ers vs Rams: meetings since 2021

DateMatchupFinalSpreadCovered
2026-09-10SF @ LASF 27, LA 7LA -3.5San Francisco 49ers by 23.5
2025-11-09LA @ SFLA 42, SF 26LA -5.5Los Angeles Rams by 10.5
2025-10-02SF @ LASF 26, LA 23LA -8.5San Francisco 49ers by 11.5
2024-12-12LA @ SFLA 12, SF 6SF -3Los Angeles Rams by 9
2024-09-22SF @ LASF 24, LA 27SF -6Los Angeles Rams by 9
2024-01-07LA @ SFLA 21, SF 20SF -5.5Los Angeles Rams by 6.5

What ATS means

ATS means against the spread. A team covers when it wins by more than the point spread, or loses by fewer points than the spread. A game that lands exactly on the spread is a push and is left out of cover percentages.

More

All Week 1 games · ATS standings · San Francisco 49ers ATS record · Los Angeles Rams ATS record

This page shows history and the posted line only. It is not a prediction.

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Regular-season games only, using each game's point spread and final score. Cover % = covers / (covers + non-covers). Past performance doesn't guarantee future results. Trifecta is not affiliated with or endorsed by the NFL or any team. Data notes. Ad: SmackTok is a paid partner. Trifecta earns a commission on sign-ups with code TRIFECTA. 21+, select states.